監(jiān)控人類細(xì)胞移植用途的抗體 (Antibodies for Detecting Human Cells Transplanted into Mice and Rats) | STEM101、STEM121、STEM123是三種小鼠來源的單克隆抗體,用于人類細(xì)胞向小鼠和大鼠移植實(shí)驗(yàn)中,監(jiān)控細(xì)胞移植、轉(zhuǎn)移、分化。 | | ■ 產(chǎn)品特點(diǎn) | · STEM101 reacts specifically with the nuclear human Ku80 protein; the antibody does not cross-react with mouse or rat Ku80 in brain tissue or cell extracts · STEM121 reacts with a human cytoplasmic protein expressed in brain, liver, pancreas, and CNS cells the antibody does not cross-react with brain tissue or cell extracts from mouse, rat, or cynomologous monkey · STEM123 reacts specifically with human GFAP, a marker of astroglial cells; the antibody does not cross-react with brain tissue or cell extracts from mouse or rat | | ■ 產(chǎn)品應(yīng)用 | · Localization, quantification, and/or characterization of engrafted cells of human origin by immunohistochemistry and immunofluorescence | | Code No. | Product | Size | Y40400 | STEM101® | 50 μg | Y40410 | STEM121® | 50 μg | Y40420 | STEM123® | 50 μg |
| | ■ 產(chǎn)品詳情 | | STEM101 detects nuclei of transplanted human neural stem cells in the olfactory bulb of a mouse brain. | | | STEM121 detects migration and differentiation of transplanted human neural stem cells in the hippocampus of a mouse brain. | | | STEM123 detects human GFAP+ astrocytes differentiated from human neural stem cells after transplantation into a mouse brain. | | 參考文獻(xiàn): | 1. Cummings BJ, et al. (2005) Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice. PNAS 102: 14069-14074. 2. Guzman R, et al. (2007) Long-term monitoring of transplanted human neural stem cells in developmental and pathological contexts with MRI. PNAS 104: 10211-10216. 3. Tamaki SJ, et al. (2009) Neuroprotection of Host Cells by Human Central Nervous System Stem Cells in a Mouse Model of Infantile Neuronal Ceroid Lipofuscinosis. Cell Stem Cell 5:310-319. 4. Salazar DL, et al. (2010) Human Neural Stem Cells Differentiate and Promote Locomotor Recovery in an Early Chronic Spinal Cord Injury NOD-scid Mouse Model. PLoS ONE 5: e12272. 5. Kelly S, et al. Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat |
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